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jbc.org - 6/26/2009
The antimalarial drug quinine disrupts Tat2p-mediated tryptophan transport and causes Trp starvation -- Khozoie et al., 10.1074/jbc.M109.005843 -- Journal of Biological Chemistry
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JBC HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: A more recent version of this article appeared on July 3, 2009 This Article Right arrow Full Text (Accepted Manuscript) Right arrow Supplemental Data Right arrow All Versions of this ...

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PhysOrg.com - latest science and technology news stories:  Tryptophan deficiency may underlie quinine side effects

Health News from Medical News Today:  Quinine Side Effects May Be Result Of Tryptophan Deficiency

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Tryptophan deficiency may underlie quinine side effects
PhysOrg.com - latest science and technology news stories — ... . This study appears in the July 3rd issue of Journal of Biological Chemistry and will be published online June 26. More information: "THE ANTIMALARIAL DRUG QUININE DISRUPTS TAT2P-MEDIATED TRYPTOPHAN TRANSPORT AND CAUSES TRP STARVATION" by Combiz Khozoie, Richard J. Pleass and Simon V. Avery. Article link: http://www.jbc.org/cgi/content/abstract/M109.005843v1 Source: American Society for Biochemistry and Molecular Biology

Quinine Side Effects May Be Result Of Tryptophan Deficiency
Health News from Medical News Today — ... deficiency induced by quinine could explain why many of quinine's side effects are localized to the head region. They also note that side-effects could be averted simply by taking dietary tryptophan supplements in conjunction with quinine treatments, though it is not yet known if tryptophan may affect quinine action against the malaria parasite. This study appears in the July 3rd issue of Journal of Biological Chemistry and was published online June 26. From the Article: "THE ANTIMALARIAL DRUG QUININE DISRUPTS TAT2P-MEDIATED TRYPTOPHAN TRANSPORT AND CAUSES TRP ...